How does an organ regrow itself?
Adult solid organs are composed of diverse cellular compartments with complex 3D organization that informs specific functions, with varying degrees of regenerative capacity in response to injury and tissue loss. While resident tissue stem cells play an important role in the regenerative process, they are located within a cellular ecosystem (or “niche”) composed of various cell types that regulate stem cell function. The Peng Lab is interested in how supportive niche cells modify the regenerative capacity of the stem cell, with the goal of deciphering cellular crosstalk that drives adaptive tissue regeneration. Our lab utilizes the lung as a model organ due to its immense cellular diversity and architectural complexity.